Beginner's Mind

#69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing

February 26, 2022 Christian Soschner Season 3 Episode 10
Beginner's Mind
#69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing
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Show Notes

Lately, investors and researchers have published more and more information on longevity research and development.

Investors like Sergey Young or  Christian Angermayer started to bet significant capital on this topic.

What is going on in this field on the research side? What are potential applications to increase the Lifespan? And when will those innovations hit the market?

In this episode, I had a conversation in December 2021  with Prof. Collin Ewald, ETH Zürich, about his longevity research and the future impact on the pharma industry.

In this episode, we talk about:

  •  What is the role of the extracellular matrix during aging and longevity?
  •  Where is currently the innovation for longevity drug discoveries done?
  •  What aging research is going on?
  • The Swiss Society of Ageing and Longevity Research
  •  And much more…

Who is the expert in the show?

Prof. Ewald is Head of the Extracellular Matrix Regeneration Laboratory, Department of Health Sciences and Technology.

Collin has a longstanding interest in the molecular biology of healthy aging and age-related pathologies.

He is the founder and currently the president of the Swiss Society for Aging Research ( He is named under the top 1000 Longevity Leaders worldwide and the top 15 Longevity Influencers in Switzerland. He has received multiple awards, including NYAS Future Entrepreneur, recognized by the New York Academy of Sciences.


(00:00) Opening about the situation in Switzerland and Austria in December 2021
(05:40) Longevity, Ageing, and the Health Span
(07:05) Collin Ewald – Development of Ageing Research since the 90s
(10:45) What is Ageing?
(16:45) What is the Possible Lifespan of Human Beings? From Stone Age to the Future
(20:10) What Factors Changed in Society that helped increase the average Lifespan?
(22:45) The Importance of Education on Healthy Aging
(26:15) How Education and Research Evolved with the Internet
(27:00) Research Focus of the Collin Ewald Lab
(33:30) Doubling the Lifespan in lab trials – is it possible to translate the research into human applications?
(35:40) How to Translate Research into Products with Spin Outs.
(38:00) Spin Outs from the Collin Ewald Lab
(47:24) The Role of Extracellular Matrix in Ageing
(54:40) The Potential for Applications for Cancer Diagnostic rooted in the research of the Collin Ewald Lab
(56:15) How Artificial Intelligence Helps in Research
(59:45) The Challenges Longevity Drug Development Faces at the Clinical Stage
(01:03:45) The Role of Food & Science in Longevity Research 
(01:07:45) The Swiss Society of Ageing Research & Health Policies
(01:13:00) Development of Life Expectancy
(01:17:20) Healthy Ageing and Social Security
(01:20:25) Advice to Young People Who Want to Create Lasting Change
(01:25:35) The Killer Experiment - How Failure Creates Success

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